Polyclonal Rabbit anti-caspase-7 (C-Terminal)

Conjugate: Purified

Immunogen: A 16 amino acid peptide from human Caspase-7 carboxy-terminus

Concentration: 1.0 mg/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: Rabbit anti Human caspase-7 antibody recognizes an epitope within the C-terminal region (CT) of Caspase-7, a ~35 kDa cysteine protease, otherwise known as ICE-like Apoptotic Protease 3 (ICE-LAP3).Caspase-7, a member of the ICE/Ced-3 subfamily, is an executioner caspase which undergoes proteolytic cleavage of its precursor to form active p12 and p20 subunits. Evidence that activation of Caspase-7 occurs during cell death induced by the cytokine death receptors Fas/APO-1 and the receptor of tumour necrosis factor (TNFR-1), coupled with the fact that granzyme-B activated Caspase-7 cleaves the nuclear enzyme poly (ADP-ribose) polymerase (PARP), suggests an important role for Caspase-7 in both cytokine-mediated and granzyme-B mediated apoptosis pathways.

• Artikelnummer: SANPS299
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: PS299
• Green Labware: Nein
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Klonalität: Polyclonal
• Methode: Immunohistochemistry (paraffin), Western Blotting
• Wirt: Rabbit