(+)-Praeruptorin B, CAS 73069-28-0

Formulation: A solid

Formal Name: (2Z,2′Z)-2-methyl-2-butenoic acid, (9S,10S)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b′]dipyran-9,10-diyl ester

Purity: ≥95%

Formula Markup: C24H26O7

Formula Weight: 426,5

Shelf life (days): 1460

CAS Number: 73069-28-0

Notes: (+)-Praeruptorin B is a pyranocoumarin that has been found in P. praeruptorum and has diverse biological activities.{36658,68550,68551,68552} It inhibits RANKL-induced osteoclastogenesis of primary mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 10 µM and LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages at 100 µM.{68550,36658} (+)-Praeruptorin B inhibits platelet aggregation induced by platelet-activating factor (PAF) in isolated rabbit platelet-rich plasma (IC50 = 50 µM) and contractions of isolated guinea pig ileum induced by histamine (Item No. 22328) or leukotriene D4 (pD2s = 4.84 and 4.34, respectively).{68551} It decreases ovariectomy-induced bone loss in a mouse model of osteoporosis when administered at a dose of 10 mg/kg. (+)-Praeruptorin B (10 µmol/animal) reduces the number of tumors initiated by 7,12-dimethylbenz[a]anthracene (DMBA; Item No. 30383) and promoted by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in a mouse two-stage model of skin carcinogenesis.{68552}

• Artikelnummer: CAY37536-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37536-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK