Procyanidin A1, CAS 103883-03-0

Formulation: A solid

Formal Name: (2R,3S,8S,14R,15R)-2,8-bis(3,4-dihydroxyphenyl)-3,4-dihydro-8,14-methano-2H,14H-1-benzopyrano[7,8-d][1,3]benzodioxocin-3,5,11,13,15-pentol

Purity: ≥98%

Formula Markup: C30H24O12

Formula Weight: 576,5

Shelf life (days): 1460

CAS Number: 103883-03-0

Notes: Procyanidin A1 is a polyphenol flavonoid dimer of (–)-epicatechin (Item No. 11807) and (+)-catechin (Item No. 70940) that has been found in R. spiciferum and has diverse biological activities.{72134,72137,72135,72136} It binds to placenta growth factor (PlGF) and VEGF (Kds = 394 and 476 nM, respectively) and increases the activity of JAK2 (EC50 = 660 nM).{72134,72137} Procyanidin A1 scavenges superoxide radicals (IC50 = 14.7 µM) and inhibits the cytopathic effects of HIV-1 in MT-4 cells (IC50 = 14 µg/ml).{72135} It increases the proliferation of isolated mouse splenocytes and peritoneal macrophages when used at concentrations ranging from 25 to 100 µM and DAMI megakaryoblasts (EC50 = 8.58 µM).{72137,72136} Procyanidin A1 (50 mg/kg) prevents decreases in the number of platelets in peripheral blood and megakaryocytes in the bone marrow in a mouse model of thrombocytopenia induced by the DNA cross-linking agent carboplatin (Item No. 13112).{72137}

• Artikelnummer: CAY38893-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38893-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK