Propoxur-d3, CAS 1219798-56-7

Formulation: A solid

Formal Name: 2-(1-methylethoxy)-phenol 1-(N-methyl-d3-carbamate)

Purity: ≥99% deuterated forms (d1-d3)

Formula Markup: C11H12D3NO3

Formula Weight: 212,3

Shelf life (days): 1460

CAS Number: 1219798-56-7

Notes: Propoxur-d3 is intended for use as an internal standard for the quantification of propoxur (Item No. 25628) by GC- or LC-MS. Propoxur is a carbamate insecticide, an inhibitor of acetylcholinesterase (IC50 = 4.3 µM), and an antagonist of α4β4 subunit-containing nicotinic acetylcholine receptors (IC50 = 165 µM for the rat receptor).{38711,39986} It is lethal to German cockroaches (B. germanica) with LD50 values of 2.45, 4.73, and 1.06 μg per insect for newly emerged males, newly emerged females, and 4-week-old nymphs, respectively. Propoxur induces lactate dehydrogenase (LDH) release from, and inhibits the growth of, flounder gill cells (IC50s = 86.59 and 89.96 μg/ml, respectively) via induction of necrosis.{39951} It also induces yolk sac and pericardial edema in zebrafish embryos when used at concentrations of 100 and 200 μg/ml. Propoxur (8.3 mg/kg) inhibits rat blood and brain cholinesterase, decreases ambulation and rearing in an open field test, and increases latency to escape foot shock after an audio stimulus in the two-way active avoidance box in rats.{39952} Formulations containing propoxur have been used in the control of insects in agriculture, as well as residential areas.

• Artikelnummer: CAY39582-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39582-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung