PROTAC BRD4 Degrader-11

Product Description: PROTAC BRD4 Degrader-11 (compound 9a) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-11 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.23 nM and 0.38 nM, respectively[1].

Applications: Cancer-programmed cell death

Formula: C61H75F2N9O12S4

References: [1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

Molecular Weight: 1292.56

Compound Purity: 99.45

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Epigenetic Reader Domain;PROTAC-Linker Conjugates for PAC;PROTACs

• Artikelnummer: MEXHY-138634-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-138634-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK