PROTAC BRD4 Degrader-13, CAS 2417370-71-7

Product Description: PROTAC BRD4 Degrader-13 (compound 9d) is a von Hippel-Lindau system-based PROTAC BRD4 degrader with a linker that can be coupled to ADC antibodies to form PACs (PROTAC-antibody Conjugates). PROTAC BRD4 Degrader-13 can be coupled to STEAP1 and CLL1 antibodies to degrade BRD4 protein in PC3 prostate cancer cells with DC50 values ​​of 0.025 nM and 6.0 nM, respectively[1].

Applications: Cancer-programmed cell death

Formula: C68H85F2N11O17P2S2

References: [1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

CAS Number: 2417370-71-7

Molecular Weight: 1492.54

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Epigenetic Reader Domain;PROTAC-Linker Conjugates for PAC

• Artikelnummer: MEXHY-138636-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-138636-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK