Product Description: PROTAC BRD4 Degrader-9 (compound 8a) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-9 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.86 nM and 7.6 nM, respectively[1].
Applications: Cancer-programmed cell death
Formula: C59H71F2N9O15S4
References: [1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.
CAS Number: 2417370-42-2
Molecular Weight: 1312.50
Compound Purity: 98.23
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Epigenetic Reader Domain;PROTACs