Purified Anti-Human CD45 Antibody(HI30), Mouse, Monoclonal

Abbreviation: CD45

Target Synonym: Receptor-type tyrosine-protein phosphatase C;Ptprc;L-CA;Ly-5;T200;CD45;

Conjugation: Unconjugated

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Clone NO.: HI30

UNIProt ID: P08575

Background: CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.

Concentration: 0.5 mg/mL

• Artikelnummer: ELSE-AB-F1137A-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-E-AB-F1137A-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Methode: Flow Cytometry
• Isotyp: Mouse IgG1 κ
• Human Gene ID: 5788
• Wirt: Mouse