Purine riboside-5'-O-triphosphate (sodium salt), CAS 35892-95-6

Formulation: A solution in water

Formal Name: 9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-9H-purine, tetrasodium salt

Purity: ≥95%

Formula Markup: C10H11N4O13P3 • 4Na

Formula Weight: 580,1

Shelf life (days): 730

CAS Number: 35892-95-6

Notes: Purine riboside-5'-O-triphosphate (PRTP) is an active metabolite of the antiviral, antibacterial, and anticancer agent nebularine (Item No. 31329).{69371} It is formed from nebularine by adenosine kinase, which results in depletion of intracellular ATP levels and induces cell death in isolated rat thymocytes, an effect that can be reduced by the adenosine kinase inhibitor 5-iodotubercidin (Item No. 10010375). PRTP is an inhibitor of DNA primase ATP and GTP polymerization activities (IC50s = 35 and 28 µM, respectively, for the human enzyme) and of calmodulin-dependent protein kinase II (CaMKII; Ki = 590 µM).{69372,69373}

• Artikelnummer: CAY38491
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38491-2.5
• Verpackungseinheit: 2.5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe