Pyruvate Dehydrogenase E1 alpha (phospho Ser293) antibody (GT1301)

Clone Name: GT1301

Application Note: WB: 1:500 - 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 43

Form: Liquid

Buffer (with preservative): PBS, 0.05% BSA, 50% Glycerol, 0.02% Sodium azide.

Concentration: 0.49 mg/ml (Please refer to the vial label for the specific concentration.)

Background: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Uniprot ID: P08559

Antigen Species: Human

Immunogen: A phospho specific peptide corresponding to residues surrounding S293 of human PDHA1.

Purification: Purified by affinity chromatography

Conjugation: Unconjugated

Full Name: pyruvate dehydrogenase E1 alpha 1 subunit

• Artikelnummer: GTX03213-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX03213-100
• Green Labware: Nein
• Verpackungseinheit: 100 μl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Western Blotting
• Isotyp: IgG
• Human Gene ID: 5160
• Wirt: Rabbit