Rabbit anti-CRM1 Antibody, Affinity Purified

Stock Concentration: 1000 µg/ml

Conjugate Type: Unconjugated

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Shelf Life: 1 year from date of receipt

Protein ID: NP_003391.1

Uniprot ID: O14980

Background: Chromosome region maintenance 1 protein homolog (CRM1) is the Ran-GTP-binding nuclear export receptor for proteins bearing a leucine rich nuclear export signal and RNAs. CRM1 also possesses a mitotic function as it localizes to kinetochores, and with Ran-GTP, recruits Ran-GTPase-activating protein (Ran-GAP1) and Ran-binding protein (Ran-BP2) for proper mitotic spindle assembly and chromosome segregation. Additionally, CRM1 is suggested to function as a loading dock of various cell cycle and checkpoint factors such as cyclins, Cdks, p53 and BRCA1, to regulate proper chromosome duplication and genomic stability.

Immunogen: Between 1021 and C-terminus

• Artikelnummer: BEYA300-469A
• Hersteller: Bethyl Laboratories
• Hersteller Artikelnummer: A300-469A
• Green Labware: Nein
• Verpackungseinheit: 100 µl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Polyclonal
• Methode: Immunoprecipitation, Western Blotting, Immunohistochemistry
• Isotyp: Whole IgG
• Human Gene ID: 7514
• Wirt: Rabbit