Rabbit anti Human Caspase-7

Rabbit anti Human Caspase-7, Polyclonal, IgG

Background: Caspase-7 along with caspase 3 and 6 form the group of effector caspases that are responsible for the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others. Caspase-7 occurs in three varient forms.Exalphas rabbit anti-human caspase-7 antibody reacts with the zymogen and with the 20-23 kDa subunit of caspase-7. Cells should be pretreated with 200 ng/ml of deoxyrubicin for one half hour. Exalphas caspase-7 antibody was generated by immunizing rabbits with the aa 186-198 of human caspase-7.

Immunogen: Rabbits with the aa 186-198 of human caspase-7.

Purification Method: Ammonium Sulfate Precipitation.

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.

References: 1. Cohen, G.M., et al. Caspases: the executioners of apoptosis. Biochem. J. 1997, 326, 1-16

2. Chandler, J.M., et al. Different subcellular distribution of Caspase-3 and Caspase-7 following Fas-induced apoptosis in mouse liver. J. Bio. Chem. 1998, 273, 10815-10818

3. Behrensdorf, H.A., et al. The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7. FEBS Lett. 2000, 466, 143-147.

UniProt: P55210.

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAA135P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: A135P
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting
• Isotyp: IgG
• Wirt: Rabbit