Rabbit anti Human Lass4

Rabbit anti Human Lass4, Polyclonal, IgG

Background: It is thought that Lass4 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.

Positive Control: Lung and embryo

Purification Method: Antigen Immunoaffiinity Purification

Concentration: Lot specific, see vial

Source: Rabbits were immunized with a synthetic peptide derived from human Lass4 protein.

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

References: 1. Min, J., et al. '(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1.' Mol. Cancer Res. 2007, 5(8):801-8122. Ruckhaberle, E., et al. 'Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.' Breast Cancer Res Treat. 2007 Dec 4 [Epub ahead of print]

UniProt: Q9HA82

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX2298P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X2298P
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting
• Isotyp: IgG
• Wirt: Rabbit
• Konjugat: Unconjugated