Rabbit anti Human Neurogenin-1

Rabbit anti Human Neurogenin-1, Polyclonal, IgG

Background: Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Efficient DNA binding requires dimerization with another bHLH protein. Expression restricted to the embryonic nervous system.

Immunogen: Synthetic peptide derived from human neurogenin-1 protein.

Purification Method: Antigen Immunoaffiinity Purification

Concentration: See vial for concentration

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

References: 1. Velkey, J.M., et al. ‘Expression of Neurogenin 1 in Mouse Embryonic Stem Cells Directs the Differentiation of Neuronal Precursors and Identifies Unique Patterns of Down-stream Gene Expression.’ Dev. Dyn., 242, 230-253 (2013)2. Hill, G.W., et al. ‘Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1.’ Stem Cells Dev., 21, 2827-2837 (2012)3. Choi, C.I., et al. ‘Neural Induction with Neurogenin 1 Enhances the Therapeutic Potential of Mesenchymal Stem Cells in an ALS Mouse Model.’ Cell Transplant., Epub ahead of print (2012)

UniProt: Q92886

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX2758P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X2758P
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting, Immunohistochemistry, Enzyme Immunoassay
• Isotyp: IgG
• Wirt: Rabbit
• Konjugat: Unconjugated