Rabbit anti Human Serine Palmitoyltransferase 1

Rabbit anti Human Serine Palmitoyltransferase 1, Polyclonal, IgG

Background: Sphingolipids play essential roles in various cellular events, including proliferation, differentiation, senescence, apoptosis, and inflammatory responses. Serine palmitoyltransferase (SPT) is the initial and rate-limiting enzyme in the de novo sphingolipid biosynthesis, and thus regulates the level of sphingolipids in cells. Immunohistochemical study revealed widespread distribution of the enzyme with most strong expression in brain and digestive tract. Two subunits, SPT1 and SPT2 at a stoichiometry of 1:1, are involved in the enzymatic activity of SPT.

Positive Control: Ubiquitously expressed

Immunogen: Synthetic peptide derived from the human serine palmitoyltransferase enzyme.

Purification Method: Antigen Immunoaffiinity Purification

Concentration: See vial for concentration

Formulation: Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08% sodium azide

References: 1. He, X., et al. (2007). Expression, activity and role of serine palmitoyltransferase in the rat hippocampus after kainate injury. J. Neurosci. Res. 85(2);423-4322. Hornemann, T., et al. (2006). Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase. J. Biol. Chem. 281(49);37275-372813. Hanada, K. (2003). Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. 1632(1-3);16-30

UniProt: O15269

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX2066P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X2066P
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting, Immunohistochemistry
• Isotyp: IgG
• Wirt: Rabbit
• Konjugat: Unconjugated