Rabbit anti Human Sphingosine 1-Phosphate Lyase 1

Rabbit anti Human Sphingosine 1-Phosphate Lyase 1, Polyclonal, IgG

Background: Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1-phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.

Positive Control: Madin-Darby Bovine Kidney (MDBK) cell lysate (Cat. No. X1007)

Immunogen: Synthetic peptide derived from the sphingosine 1-phosphate lyase 1 protein.

Purification Method: Antigen Immunoaffiinity Purification

Concentration: Lot specitic, see vial label

Formulation: Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08% sodium azide

References: 1. Van Veldhoven P.P., et al; Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22. Biochim. Biophys. Acta 1487:128-134(2000).2. Reiss U., et al; Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J. Biol. Chem. 279:1281-1290(2004).3. Nagase T., et al; Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.; DNA Res. 6:337-345(1999).4. Strausberg R.L., et al; Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).

UniProt: O95470

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX1631P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X1631P
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus), Cow (Bovine)
• Klonalität: Polyclonal
• Methode: Western Blotting
• Isotyp: IgG
• Wirt: Rabbit
• Konjugat: Unconjugated