Rabbit anti Human Sphingosine Kinase 2, Long Form

Rabbit anti Human Sphingosine Kinase 2, Long Form, Polyclonal, IgG

Background: Rat sphingosine kinase 1 catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (spp)(sphingosine + ATP = sphingosine 1-phosphate + ADP), a lipid mediator with both intra- and extracellular functions. also acts on d-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as d,l-threo-dihydrosphingosine, n,n-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. The long form of sphingosine kinase 1, an N-terminal extension, is responsible for FceRI-mediated calcium mobilization and may play a role in other ligand mediated signaling events.

Positive Control: Jurkat lysate used as positive control.

Immunogen: Synthetic peptide derived from the N-terminal extension of the Sphingosine Kinase 2-L protein.

Purification Method: Antigen Immunoaffiinity Purification

Concentration: Lot specific, see vial

Formulation: Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08% sodium azide

References: 1. Okada, T., et al. 'Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis.' J. Biol. Chem. 2005, 280, 36318-36325

UniProt: Q9NRA0

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX1880P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X1880P
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting, ELISA
• Isotyp: IgG
• Wirt: Rabbit
• Konjugat: Unconjugated