Rabbit anti Human Survivin (NT) (TIAP) (Inhibitor of Apoptosis)

Rabbit anti Human Survivin (NT) (TIAP) (Inhibitor of Apoptosis), Polyclonal, IgG

Background: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP1-3. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas1,3.

Positive Control: MOLT4 cell lysate.

Immunogen: Antibody raised against a synthetic peptide corresponding to amino acids 1 to 12 of the human survivin protein.

Purification Method: Antigen Immunoaffiinity Purification.

Formulation: Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative.

References: 1. Ambrosini, G., et al. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 1997, 3, 917-921

2. Li, F., et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998, 396, 580-584

3. Kobayashi, K., et al. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc. Natl. Acad. Sci. USA 1999, 96, 1457-1462.

UniProt: O15392.

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX1131P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X1131P
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting
• Isotyp: IgG
• Wirt: Rabbit