Rabbit anti Human TOB (Transducer of HER2/neu/erbB-2)

Rabbit anti Human TOB (Transducer of HER2/neu/erbB-2), Polyclonal, IgG

Background: Rabbit anti-human TOB (Transducer Molecule of erbB-2) reacts with a 45 kDa protein originally identified as a molecule that interacts with the ErbB-2 protein, a receptor protein tyrosine kinase (RPTK). TOB does not contain either SH2 or SH3 domains but is homologous with the N terminus of the anti-proliferative BTG-1 protein. Like BTG-1, TOB when exogenously expressed, is able to suppress the growth of NIH3T3 cells. This growth suppression is hindered by the presence of kinase-active p185erbB2.

Positive Control: HeLa cell lysate.

Immunogen: Synthetic peptide derived from the TOB protein.

Purification Method: Ammonium Sulfate Precipitation.

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.

References: 1. Matsuda, S., et al. 'Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.' Oncogene 1996: 12, 705-713.

UniProt: P50616.

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXAX1552P
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: X1552P
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Polyclonal
• Methode: Western Blotting
• Isotyp: IgG
• Wirt: Rabbit