Stock Concentration: 1000 µg/ml
Conjugate Type: Unconjugated
Buffer: Phosphate Buffered Saline (PBS) with 0.09% Sodium Azide, BSA-Free
Shelf Life: 1 year from date of receipt
Protein ID: NP_000870.1
Uniprot ID: P05113
Background: IL-5 is a homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. IL-5 also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. IL-5 exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P05113].
Immunogen: residues 20-134
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