Rabbit anti-MDR1 / P Glycoprotein 1 antibody, clone SQab30342 (monoclonal)

Clone Number: SQab30342

Immunogen: Recombinant protein fragment of MDR1 / P Glycoprotein 1

Concentration: n/a

Format: Purification with Protein A.

Storage buffer: PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.

Additional info: Application note: Storage instruction: For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Applications: IHC-P

• Artikelnummer: SANMON240312
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON240312
• Verpackungseinheit: 100 ul
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Wirt: Rabbit
• Konjugat: Unconjugated