Rabbit anti-PD-L1 Recombinant Monoclonal Antibody (BLR227K)

Stock Concentration: 100 µg/ml

Conjugate Type: Unconjugated

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide

Shelf Life: 1 year from date of receipt

Protein ID: NP_054862.1

Uniprot ID: Q9NZQ7

Background: PD-L1 is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma [taken from NCBI Entrez Gene (Gene ID: 55193)].

Immunogen: Residues 19-238 (ECD)

• Artikelnummer: BEYA700-227
• Hersteller: Bethyl Laboratories
• Hersteller Artikelnummer: A700-227
• Verpackungseinheit: 100 µl (10 blots)
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: Immunoprecipitation, Western Blotting, Flow Cytometry
• Isotyp: Whole IgG
• Human Gene ID: 29126
• Wirt: Rabbit
• Konjugat: Unconjugated