Rabbit anti-PVR/CD155 Recombinant Monoclonal Antibody (BLR074G)

Stock Concentration: 1000 µg/ml

Conjugate Type: Unconjugated

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.09% Sodium Azide, BSA-Free

Shelf Life: 1 year from date of receipt

Protein ID: NP_006496.4

Uniprot ID: P15151

Background: PVR/CD155 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It mediates NK cell adhesion and triggers NK cell effector functions. PVR/CD155 binds two different NK cell receptors: CD96 and CD226, and these interactions accumulate at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. PVR/Cd155 also promotes NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. PVR/CD155 also plays a role in mediating tumor cell invasion and migration. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P15151]."

Immunogen: Residues 28-329 (ECD)

• Artikelnummer: BEYA700-074CF
• Hersteller: Bethyl Laboratories
• Hersteller Artikelnummer: A700-074CF
• Verpackungseinheit: 100 µl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: Western Blotting, Flow Cytometry, Immunohistochemistry, Immunocytochemistry
• Isotyp: Whole IgG
• Human Gene ID: 5817
• Wirt: Rabbit
• Konjugat: Unconjugated