Rabbit anti-STAT3-pY705 Recombinant Monoclonal Antibody (BLR231K)

Stock Concentration: 500 µg/ml

Conjugate Type: Unconjugated

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide

Shelf Life: 1 year from date of receipt

Protein ID: NP_644805.1

Uniprot ID: P40763

Background: STAT3 (signal transducer and activator of transcription 3) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein [taken from NCBI Entrez Gene (GeneID:6774)].

Immunogen: Surrounding Tyrosine 705

• Artikelnummer: BEYA700-231
• Hersteller: Bethyl Laboratories
• Hersteller Artikelnummer: A700-231
• Green Labware: Nein
• Verpackungseinheit: 100 µl (50+ tests)
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Immunoprecipitation, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Isotyp: Whole IgG
• Human Gene ID: 6774
• Wirt: Rabbit