Rabbit anti-TFEB Recombinant Monoclonal Antibody (BLR070G)

Stock Concentration: 1000 µg/ml

Conjugate Type: Unconjugated

Buffer: Phosphate Buffered Saline (PBS) with 0.09% Sodium Azide, BSA-Free

Shelf Life: 1 year from date of receipt

Protein ID: NP_009093.1

Uniprot ID: P19484

Background: Transcription factor EB (TFEB) specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. TFEB specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression; thus, TFEB plays a central role in expression of lysosomal genes. TFEB also specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P19484].

Immunogen: Between 426 and C-terminus

• Artikelnummer: BEYA700-070CF
• Hersteller: Bethyl Laboratories
• Hersteller Artikelnummer: A700-070CF
• Green Labware: Nein
• Verpackungseinheit: 100 µl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Immunoprecipitation, Western Blotting, Flow Cytometry
• Isotyp: Whole IgG
• Human Gene ID: 7942
• Wirt: Rabbit