Radicicol, CAS 12772-57-5

Hsp90 inhibitor

Product Type: Inhibitor

CAS No.: 12772-57-5

MolecularFormula: C18H17CIO6

Molecular Weight: 364,8

Source: Produced by fermentation

Purity: 97% by TLC

Solubility: Soluble in DMSO

Appearance: White to Yellow Solid

PubChem CID: 6323491

Scientific Background: Radicicol inhibits src (IC50=0.27µM) and src-like kinases(1), leading to hypophosphorylation of retinoblastoma tumor suppressor protein(2). It causes morphological reversion of ras-transformed cells(3) and leads to selective depletion of Raf kinase(4). It also displays anti-angiogenic activity(5), and binds to and inhibits Hsp 90 molecular chaperone(6). It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1. Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.

References: 1. Kwon H.J., et al. (1992) Cancer Res. 52: 6929.2. Yen A., et al. (1994) Exp.Cell Res. 214: 163.3. Kwon H.J., et al. (1995) J.Biochem.(Tokyo) 118: 221.4. Soga S., et al. (1998) J.Biol.Chem. 273: 822.5. Oikawa T., et al. (1993) Eur.J.Pharmacol. 241: 221.6. Roe S.M. et al. (1999) J.Med.Chem. 42: 260.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-117A
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-117A
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Reaktivität: Human