Rapamycin, CAS 53123-88-9

mTOR inhibitor

Product Type: Inhibitor

CAS No.: 53123-88-9

MolecularFormula: C51H79NO13

Molecular Weight: 914,18

Source: Synthetic

Purity: >98%

Solubility: Soluble to 100 mM in ethanol, and to 50 mM in DMSO

Appearance: White Solid

PubChem CID: 5284616

Scientific Background: Rapamycin or Sirolimus is an immunosuppressant and antifungal. It inhibits the response to interleukin-2, and therefore blocks activation of T and B cells. It binds FKBP12 which then inhibits the mTOR pathway (1). There is also potential treatment for Alzheimer;s, autism and HIV infection (2-3).

References: 1. Gruppuso P.A., Boylan J.M., and Sanders J.A. (2011) Cell Cycle. 10(7): EPub.2. Ehninger D., et al. (2008) Nat. Med. 14(8): 843-848.3. Donia M., McCubrey J.A., Bendtzen K., and Nicoletti F. (2010) Br J Clin Pharmacol. 70(6): 784-793.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-212-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-212-5MG
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK