Rat anti-Mouse SIGN-R1, clone ER-TR9 (Monoclonal)

Clone Number: ER-TR9

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: 200 ug/ ml

Storage buffer: Sterile cell culture medium with 0.02% sodium azide

Additional info: The monoclonal antibody ER-TR9 recognizes murine SIGN-related 1 (SIGN-R1). Mouse SIGN-R1,- a homolog of human DC-SIGN, is a 37 kDa type II transmembrane protein containing a single, C-terminal C-type lectin domain. SIGN-R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in the peritoneal cavity of some mouse strains. ER-TR9 does not react with macrophages in other regions of the spleen, such as CD169+ marginal metallophils and F4/80+ red pulp macrophages. In the spleen, the MZM function in trapping and clearance of blood-borne microbial antigens. SIGN-R1 mediates the uptake of encapsulated microbes , particularly through the recognition of microbial polysaccharides. Uptake of FITC-labeled dextran by macrophages can be blocked both in vivo and in vitro by the monoclonal antibody ER-TR9. Therefore, the monoclonal antibody ER-TR9 can be used to study the uptake of polysaccharides by macrophages.

References: Dijkstra; C; et al. Immunology 1985; 55: 23/Kretschmer, K, et al J Immunol 2003, 171: 6495/Kang; Y et al. PNAS 2004; 101: 215

• Artikelnummer: SANMON7056
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON7056
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (frozen), Flow Cytometry, Functional Assay
• Isotyp: IgM
• Wirt: Rat