Recombinant Human ABCG2 protein (His tag)

Abbreviation: ABCG2

Target Synonym: Broad substrate specificity ATP-binding cassette transporter ABCG2;ABCG2;ATP-binding cassette sub-family G member 2;Breast cancer resistance protein;CDw338

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: Q9UNQ0

Background: Hematopoietic stem cells are known to express a membrane transporter molecule, known as P-glycoprotein (Pgp), that is encoded by the multidrug resistance gene 1 (MDR1) . Expression of Pgp appears to confer a proliferative advantage to stem cells through its anti-apoptotic effects . An additional transporter molecule known as ABCG2 (ATP-binding cassette gene 2) or Bcrp1 (Breast cancer resistance protein 1), first identified in a breast cancer cell line , is expressed on stem cells . ABCG2 belongs to a family of molecules that span the cell membrane six times and can exist as either homo or hetero dimers linked by a short intracellular flexible linker region that plays an important role in the efflux of a wide range of substrates

Sequence: Met 1-Gly 300

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDEH100426-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDEH100426-20
• Green Labware: Nein
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK