Recombinant Human B7-H3/CD276 Protein (His Tag)

Abbreviation: B7-H3;CD276

Target Synonym: CD276;B7H34Ig-B7-H3;B7-H3;B7 homolog 3;CD276 antigen;CD276 molecule;Costimulatory molecule

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: Q5ZPR3

Background: CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.

Sequence: Leu29-Thr461

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: < 1.0 EU per ug of the protein as determined by the LAL method.

• Artikelnummer: ELSPDMH100007-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDMH100007-20
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK