Description: BDNF belongs to the NGF family of neurotrophic growth factors, supporting neuron growth and survival. It binds to a low-affinity cell surface receptor, LNGFR, shared with other neurotrophins like NGF, NT-3, and NT-4. However, BDNF primarily exerts its neurotrophic effects through the high-affinity receptor gp145/trkB. Structurally, BDNF is part of a 247 amino acid polypeptide precursor, featuring an 18 amino acid signal sequence and a 110 amino acid propeptide. Recombinant Human/Murine/Rat BDNF exists as a 27.0 kDa homodimer comprising two 120 amino acid subunits held together by robust non-covalent interactions.
Expression System: E. coli
Molecular Weight: 27 kDa
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Form: Lyophilized
Contains: no preservative
Storage Conditions: -20°C
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: BDNF
Protein ID: P23560
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