Recombinant Human BTN3A1/CD277 protein (His tag)

Abbreviation: BTN3A1;CD277

Target Synonym: Butyrophilin subfamily 3 member A1;CD277;BTN3A1;BTF5

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: O00481

Background: Butyrophilin Subfamily 3 Member A1 (BTN3A1/CD277) is a type I transmembrane glycoprotein member of the Ig superfamily. It is expressed on a wide variety of immune cells. Similar to BTN3A2 and BTN3A3, BTN3A1 is composed of an extracellular N-terminal IgV and a membraneproximal IgC domain followed by a transmembrane domain and a cytoplasmic tail. These Ig domains are also found in B7 family costimulatory molecules, suggesting structural and functional similarities between the two protein families. BTN3A1 acts as a critical protein for the activation of Vγ9Vδ2 T cells following detection of distressed cells. The anti-tumor responses of Vγ9Vδ2 T cells may be enhanced with agonistic anti-BTNA3 antibodies.

Sequence: Met1-Gly254

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDMH100143-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDMH100143-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK