Recombinant Human CD247/CD3-ZETA Protein(His,SUMO)

Abbreviation: CD247;CD3-ZETA

Target Synonym: CD3-ZETA;CD3H;CD3Q;CD3Z;IMD25;T3Z;TCRZ

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-His-SUMO

UNIProt ID: P20963

Background: CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

Sequence: Arg52-Arg164

Purity: > 85 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile 20mM Tris-HCl, 150 mM NaCI, 1 mM DTT ( pH 8.0), Mannitol, Proclin300, Tween 80
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDEH100031-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDEH100031-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK