Recombinant Human CDNF/ARMETL1 Protein (His Tag)

Abbreviation: CDNF;ARMETL1

Target Synonym: Cerebral dopamine neurotrophic factor;ARMET-like protein 1;Conserved dopamine neurotrophic factor;ARMETL1

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: Q49AH0

Background: Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family. CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.

Sequence: Gln25-Leu187

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: < 1.0 EU per ug of the protein as determined by the LAL method.

• Artikelnummer: ELSPDMH100008-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDMH100008-20
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK