Recombinant Human CXCR4 (C28A) Protein (His Tag)

Abbreviation: CXCR4

Target Synonym: C-X-C chemokine receptor type 4;CD184;FB22;Fusin;HM89;HSY3RR;LAP3;LCR1;NPYR;SDF 1 receptor;WHIM

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-GST

UNIProt ID: P61073

Background: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.

Sequence: Met1-Lys38

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDEH100054-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDEH100054-20
• Green Labware: Nein
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK