Recombinant Human E2F2 protein (His tag)

Abbreviation: E2F2

Target Synonym: Transcription factor E2F2;E2F2;

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: Q14209

Background: E2F-2 (viral E2-associated factor 2) is a 50?55 kDa member of the E2F/DP family of transcription factors. It is principally expressed by placenta, and forms a DNA?activating E2F heterodimeric complex with DP-1 or -2. This complex, when active, promotes cell cycle progression. In quiescent cells, association with the retinoblastoma-tumor suppressor gene product termed pRB suppresses its activity. Human E2F?2 is 437 amino acids (aa) in length and contains a CDK2 binding region (aa 65?105), a DNA?binding domain (aa 107?196), a dimerization segment (aa 197?289), a transactivation region (aa 359?437), and a pRB binding domain (aa 410?427). There are two potential alternate start sites at Met197 and Met342, and one splice variant that shows a two aa substitution for aa 349?437.

Sequence: Ala 65-Asn 437

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDEH100410-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDEH100410-20
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK