Description: GM-CSF, a hematopoietic growth factor, plays a role in stimulating the development of neutrophils and macrophages while also supporting the proliferation and maturation of early erythroid, megakaryocytic, and eosinophilic progenitor cells. It's primarily produced in endothelial cells, monocytes, fibroblasts, and T-lymphocytes. GM-CSF has the additional effect of inhibiting neutrophil migration and boosting the functional activity of mature end cells. Unlike G-CSF, GM-CSF molecules are species-specific with no cross-reactivity between Human and murine versions. Recombinant Human GM-CSF is a 14.6 kDa globular protein comprising 128 amino acids, featuring two intramolecular disulfide bonds and two potential N-linked glycosylation sites.
Expression System: E. coli
Molecular Weight: 14.6 kDa
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.
Form: Lyophilized
Contains: no preservative
Storage Conditions: -20°C
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: CSF2
Protein ID: P04141
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