Description: IL-3 acts as a crucial hematopoietic growth factor, supporting the survival, differentiation, and proliferation of specialized progenitor cells spanning various lineages such as megakaryocytes, granulocyte-macrophages, erythrocytes, eosinophils, basophils, and mast cells. It is produced by T cells, mast cells, and eosinophils, contributing significantly to processes like thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. IL-3 also triggers monocyte activation, suggesting potential additional roles in immunoregulation. Many of its effects hinge on co-stimulation with other cytokines. Notably, IL-3 shows species-specific variability in glycosylation patterns. The recombinant Human IL-3 is a 15.0 kDa globular protein comprising 133 amino acid residues
Expression System: E. coli
Molecular Weight: 15 kDa
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.
Form: Lyophilized
Contains: no preservative
Storage Conditions: -20°C
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: IL3
Protein ID: P08700
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