Recombinant Human IL6RA/CD126 protein (His tag)

Abbreviation: IL6RA;CD126

Target Synonym: Interleukin-6 receptor subunit alpha;IL-6R subunit alpha;IL-6R-alpha;IL-6R 1;Membrane glycoprotein 80;gp80;CD126;IL-6R;IL-6R-1;IL-6RA;IL6Q;IL6RQ

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: P08887

Background: Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

Sequence: Met1-Pro365

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDMH100089-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDMH100089-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK