Description: NT-3, a neurotrophic factor, shares structural kinship with β-NGF, BDNF, and NT-4, all part of the cysteine-knot family of growth factors known for their stable dimeric structures. It's predominantly expressed by neurons in the central nervous system and activates signaling pathways through the trk receptors. NT-3 plays a vital role in promoting the growth and survival of both nerve cells and glial cells. Notably, the amino acid sequences of Human, murine, and rat NT-3 are identical. Recombinant Human NT-3 forms a noncovalently linked homodimer consisting of two 13.6 kDa polypeptide monomers, totaling 240 amino acid residues.
Expression System: E. coli
Molecular Weight: 27.2 kda
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Form: Lyophilized
Contains: no preservative
Storage Conditions: -20°C
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: NTF3
Protein ID: P20783
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