Description: NT-4 is a neurotrophic factor sharing structural similarities with β-NGF, BDNF, and NT-3, all part of the cysteine-knot family of growth factors characterized by stable dimeric structures. It is expressed in various tissues such as the prostate, thymus, placenta, and skeletal muscle. NT-4 can activate signaling pathways through the LNGFR and trkB receptors, leading to the survival of peripheral sensory sympathetic neurons. Recombinant Human NT-4 exists as a noncovalently linked homodimer comprising two 14.0 kDa polypeptide monomers, totaling 260 amino acid residues.
Expression System: E. coli
Molecular Weight: 28.1 kDa
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Form: Lyophilized
Contains: no preservative
Storage Conditions: -20°C
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: NTF4
Protein ID: P34130
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