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Protein Tag: C-His
Uniprot: P23510
Accession: P23510
Background: Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed on the surface of activated B cells,T cells,dendritic cells and endothelial cells. OX40L binds to OX40(CD134),a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proliferation and cytokine production. Additional,it has been found association with systemic lupus erythematosus,no association with occurrence of atherosclerosis.
Bio Acitivity: Not validated for activity
Sequence: Gln51-Leu183
Purity: > 95% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.
Calculated MW: 14.5 kDa
Observed MW: 30 kDa
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