Description: VEGF stands out as a potent cytokine, driving growth and angiogenesis. It fosters endothelial cell proliferation and survival, contributing significantly to angiogenesis and vascular permeability. Its expression in vascularized tissues plays a crucial role in both normal and abnormal angiogenesis. VEGF's involvement is notable in tumor metastasis induction and intraocular neovascular syndromes. VEGF signals through three receptors: fms-like tyrosine kinase (flt-1), the KDR gene product (with the murine equivalent being the flk-1 gene product), and the flt4 gene product. Recombinant Human VEGF165 is a 38.2 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.
Expression System: E. coli
Molecular Weight: 38.2 kDa
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-8.0 ng/ml.
Form: Lyophilized
Contains: no preservative
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: VEGFA
Protein ID: P15692
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