Recombinant Mouse IL-1ra/IL-1F3 protein (His tag)

Abbreviation: IL-1ra;IL-1F3

Target Synonym: IL-1RN;IL-1ra;IRAP;IL1 inhibitor;Il1rn;Interleukin-1 Receptor Antagonist Protein

Target Species: Mouse

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: P25085

Background: Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and IL-1 alpha, respectively. Il1rn can Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling, but has no interleukin-1 like activity. Recently, an recombinant human Il1rn protein is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.

Sequence: Arg27-Gln178

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDMM100014-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDMM100014-20
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK