Recombinant Mouse IL-33 protein (His tag)

Abbreviation: IL-33

Target Synonym: Interleukin 33;IL-33;IL33;C9orf26;NKHEV;Interleukin-1 family member 11;DVS27;NF-HEV and IL- 1F11

Target Species: Mouse

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: Q8BVZ5

Background: Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up-regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL-1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1. BindingIL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs.

Sequence: Ser 109-Ile 266

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDEM100058-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDEM100058-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK