Description: TPO, a lineage-specific growth factor, originates from the liver, kidney, and skeletal muscle. It triggers the growth and development of megakaryocytes, leading to higher platelet levels in the bloodstream. TPO communicates through the c-mpl receptor, playing a crucial role in platelet regulation. Both human and murine TPO can interact across species. The Recombinant Murine TPO, comprising 174 amino acids (18.7 kDa), is biologically active, encompassing the erythropoietin-like domain of the complete TPO protein.
Expression System: E. coli
Molecular Weight: 18.7 kDa
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.
Form: Lyophilized
Contains: no preservative
Storage Conditions: -20°C
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: Thpo
Protein ID: P40226
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