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Recombinant Rat AIF-M1 protein (His tag)

Recombinant Rat AIF-M1 protein (His tag)
Artikelnummer
ELSPDER100205-100
Verpackungseinheit
100μg
Hersteller
Elabscience Biotechnology

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Protein Tag: N-His

Uniprot: Q9JM53

Accession: Q9JM53

Background: Probable oxidoreductase that has a dual role in controlling cellular life and death, during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces "parthanatos" i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

Bio Acitivity: Not validated for activity

Sequence: Arg 150-Val 299

Purity: > 95% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Endotoxin: < 10 EU/mg of the protein as determined by the LAL method.

Calculated MW: 16.4 kDa

Observed MW: 18 kDa
Mehr Informationen
Artikelnummer ELSPDER100205-100
Hersteller Elabscience Biotechnology
Hersteller Artikelnummer PDER100205-100
Verpackungseinheit 100μg
Mengeneinheit STK
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