Recombinant Rat Interleukin-12 subunit beta/IL-12B protein (His tag)

Abbreviation: IL-12B

Target Synonym: Interleukin-12 subunit beta;Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12 subunit p40;Il12b;rCG_35081

Target Species: Rat

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: E9PU71

Background: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.

Sequence: Met1-Ser335

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDMR100029-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDMR100029-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK