Recombinant Rat NAMPT/PBEF protein (His tag)

Abbreviation: NAMPT;PBEF

Target Synonym: Nicotinamide phosphoribosyltransferase;NAmPRTase;Nampt;Pre-B-cell colony-enhancing factor 1 homolog;PBEF;Visfatin

Target Species: Rat

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: Q80Z29

Background: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.

Sequence: Met1-His491

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDER100040-20
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDER100040-20
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK