Recombinant Rat TGFBR1 protein (His tag)

Abbreviation: TGFBR1

Target Synonym: AAT5;Activin receptor like kinase 5;ACVRLK4;ALK-5;LDS1A;LDS2A;MSSE;SKR4;TbetaR I;TGF-beta receptor type-1;TGFBR1;Transforming growth factor beta receptor 1

Target Species: Rat

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: P80204

Background: Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I receptor, originally known as ALK-5 (Activin receptor?like kinase) is also a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.

Sequence: Leu 311-Met 501

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• Artikelnummer: ELSPDER100074-100
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-PDER100074-100
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK